| name | Adapalene (Differin) |
| classification | Topical retinoid |
| pharmacokinetics | Adapalene is a topical retinoid. It is well-absorbed through the skin. Metabolism primarily occurs in the liver. Excretion is primarily in the feces. Plasma protein binding is low. |
| suggested dosage | | general | Typically, a thin film of Differin (adapalene) cream, gel, or solution is applied to the affected skin once daily at bedtime. The specific formulation and dosage should be followed as prescribed by a healthcare professional. Lower concentrations are often appropriate to start with. Individualized treatment is required and the dosage will vary. | | male patient 25 70kg | A healthcare professional should determine the appropriate dosage based on the severity of the acne, individual patient factors, and potential side effects. Starting with a lower concentration and frequency, as instructed by a physician, is generally recommended. This information does not constitute medical advice. |
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| indications | Treatment of acne vulgaris, including inflammatory lesions and comedones (blackheads and whiteheads). |
| safety in pregnancy | Adapalene is not recommended during pregnancy unless the potential benefits outweigh the potential risks. Limited data suggests that adapalene may cause birth defects, though more robust studies are needed. Consult with a healthcare professional for guidance. |
| safety in breastfeeding | Adapalene is not recommended for use in breastfeeding women. It may be present in breast milk and its effects on the infant are unknown. Consult with a healthcare professional. |
| side effects | | 1 | Skin irritation (redness, dryness, burning, peeling, or itching) | | 2 | Exacerbation of pre-existing skin conditions | | 3 | Erythema (redness) | | 4 | Papules (small bumps) | | 5 | Pustules (small pus-filled bumps) | | 6 | Photosensitivity (increased skin sensitivity to sunlight): Wear sunscreen when outdoors. | | 7 | Less common: skin reactions like contact dermatitis or allergic reactions |
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| alternatives | |
| contraindications | Known hypersensitivity to adapalene or any component of the medication. |
| interactions | Limited drug interactions are known for topical adapalene. However, consult a healthcare professional if you are taking other medications, especially topical or systemic retinoids, or medications that could affect the liver or skin. |
| warnings and precautions | | 1 | Avoid use on broken or irritated skin. | | 2 | Use only as directed by a healthcare professional. | | 3 | Do not use with other topical retinoids without consulting a physician. | | 4 | Discontinue use and contact your healthcare provider if any serious skin reactions occur. |
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| additional informations | Adapalene is generally well-tolerated. It may take several weeks to notice a significant improvement in acne. Consistency with the treatment plan is essential for optimal results. Always consult with a dermatologist or other qualified healthcare professional for personalized advice and monitoring. |
| patient profile | |
