| name | Augmentin |
| classification | Penicillin-based antibiotic, specifically a combination of amoxicillin (a penicillin) and clavulanate potassium (a beta-lactamase inhibitor). |
| pharmacokinetics | | absorption | Amoxicillin is well absorbed after oral administration. Clavulanate enhances absorption of amoxicillin, resulting in higher concentrations in the blood. | | distribution | Both drugs distribute widely throughout the body, including the lungs, kidneys, and tissues. | | metabolism | Amoxicillin is primarily excreted unchanged in urine. Clavulanate is primarily metabolized by the liver and excreted in the urine and bile. | | excretion | Elimination is primarily renal, with a significant portion of amoxicillin and clavulanate excreted in the urine. |
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| suggested dosage | | adult | The dosage of Augmentin varies depending on the specific indication and severity of infection. A doctor should determine the appropriate dosage and duration of treatment. Dosage information is available in the package insert. | | note | Consult a healthcare professional for specific dosage instructions, especially for a patient with underlying health conditions. Weight and age may also influence the dosage, and the 70kg weight is important context but does not determine the dosage on its own. |
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| indications | Augmentin is used to treat a variety of bacterial infections, including respiratory tract infections (e.g., bronchitis, pneumonia), skin infections, urinary tract infections, and more. It is particularly effective against bacteria that produce beta-lactamases, enzymes that can break down penicillin. |
| safety in pregnancy | | classification | Category B. Augmentin is generally considered safe during pregnancy, but the benefits and risks should be carefully evaluated by the physician, especially during the first trimester. | | additional notes | Consult with your doctor during pregnancy. |
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| safety in breastfeeding | | classification | Data is limited regarding the transfer of amoxicillin and clavulanate into breast milk; however, the levels are generally considered low and unlikely to cause adverse effects in the infant. Discuss with your doctor whether Augmentin is appropriate. | | additional notes | Consult with your doctor. |
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| side effects | | 1 | Nausea, vomiting, diarrhea, abdominal pain | | 2 | Skin rashes, itching (urticaria) | | 3 | Headache, dizziness | | 4 | Allergic reactions (rare but can be severe) | | 5 | Superinfection (e.g., yeast infections) |
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| alternatives | |
| contraindications | | 1 | Known allergy to penicillin or cephalosporins | | 2 | Severe kidney disease |
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| interactions | Augmentin can interact with several medications, including other antibiotics, blood thinners, and some drugs used to treat heart conditions. Inform your doctor about all medications you are currently taking. |
| warnings and precautions | | 1 | Monitor for signs of allergic reactions, especially in patients with a history of allergies | | 2 | Monitor kidney function | | 3 | Be cautious in patients with liver disease | | 4 | Do not abruptly stop taking the medication without consulting your doctor | | 5 | Inform your doctor of any history of gastrointestinal conditions. |
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| additional information | | patient age | 25 | | patient weight | 70 | | important note | This information is for educational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional for diagnosis, treatment, and any questions regarding your health. This document does not provide comprehensive information on all possible interactions and considerations. The information provided may not be applicable in all cases. Detailed information regarding warnings, side effects, dosage, etc. should be obtained from the prescribed drug's package insert. |
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