name | Benadryl (diphenhydramine) |
classification | Antihistamine, H1 receptor antagonist |
pharmacokinetics | absorption | Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations typically reached within 1-2 hours after oral administration. | distribution | Distributed throughout the body, crossing the blood-brain barrier. | metabolism | Primarily metabolized in the liver, and the metabolites are excreted through the kidneys. | excretion | Excreted primarily in the urine. |
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suggested dosage | adult | 25-50 mg orally every 4-6 hours as needed, or as directed by a healthcare professional. | note | Dosage may vary depending on the specific condition being treated and the individual patient's response. |
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indications | 1 | Seasonal allergic rhinitis (hay fever) | 2 | Urticaria (hives) | 3 | Angioedema | 4 | Motion sickness | 5 | Mild insomnia | 6 | Post-operative itching |
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safety in pregnancy | category | Category B | note | Generally considered safe in pregnancy, but use should be considered only when potential benefits outweigh risks, and under the strict guidance of a healthcare professional. |
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safety in breastfeeding | note | Small amounts are excreted into breast milk. It may be prudent to avoid during breastfeeding or use with caution, under the guidance of a healthcare professional. |
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side effects | 1 | Drowsiness | 2 | Dry mouth | 3 | Blurred vision | 4 | Constipation | 5 | Difficulty urinating | 6 | Nausea | 7 | Vomiting | 8 | Loss of appetite | 9 | Nervousness | 10 | Hallucinations (rare, but more likely in high doses or in those with underlying mental health issues) | 11 | Urinary retention |
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alternatives | |
contraindications | 1 | Known hypersensitivity or allergy to diphenhydramine or related compounds | 2 | Severe liver or kidney disease | 3 | Angle-closure glaucoma | 4 | Prostatic hypertrophy | 5 | Severe respiratory insufficiency |
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interactions | 1 | Alcohol | 2 | Other central nervous system depressants (e.g., opioids, benzodiazepines) | 3 | MAOIs | 4 | Anticholinergic medications | 5 | Other medications that can cause drowsiness or sedation |
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warnings and precautions | 1 | May impair mental alertness and motor skills. | 2 | Use with caution in patients with asthma or other respiratory conditions, as it may worsen symptoms. | 3 | Avoid driving or operating machinery after taking the medication. | 4 | Use with caution in patients with a history of cardiovascular disease or seizures. | 5 | Consult a doctor if symptoms persist or worsen. |
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additional information | patient specific considerations | age | Benadryl is generally safe for use in a 25-year-old male, but dosage and use should be guided by a healthcare professional. | weight | Dosage should be adjusted according to individual needs and response; a healthcare provider can provide personalized guidance. | other factors | Pre-existing health conditions, other medications or supplements being taken are all factors in deciding the safest dosage and usage. |
| special notes | This information is for educational purposes only and should not be considered medical advice. Always consult with a healthcare professional for any health concerns or before making any decisions related to your health or treatment. |
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