Benadryl

Drug Overview

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drug details
nameBenadryl (diphenhydramine)
classificationAntihistamine, H1 receptor antagonist
pharmacokinetics
absorptionRapidly absorbed from the gastrointestinal tract, with peak plasma concentrations typically reached within 1-2 hours after oral administration.
distributionDistributed throughout the body, crossing the blood-brain barrier.
metabolismPrimarily metabolized in the liver, and the metabolites are excreted through the kidneys.
excretionExcreted primarily in the urine.
suggested dosage
adult25-50 mg orally every 4-6 hours as needed, or as directed by a healthcare professional.
noteDosage may vary depending on the specific condition being treated and the individual patient's response.
indications
1Seasonal allergic rhinitis (hay fever)
2Urticaria (hives)
3Angioedema
4Motion sickness
5Mild insomnia
6Post-operative itching
safety in pregnancy
categoryCategory B
noteGenerally considered safe in pregnancy, but use should be considered only when potential benefits outweigh risks, and under the strict guidance of a healthcare professional.
safety in breastfeeding
noteSmall amounts are excreted into breast milk. It may be prudent to avoid during breastfeeding or use with caution, under the guidance of a healthcare professional.
side effects
1Drowsiness
2Dry mouth
3Blurred vision
4Constipation
5Difficulty urinating
6Nausea
7Vomiting
8Loss of appetite
9Nervousness
10Hallucinations (rare, but more likely in high doses or in those with underlying mental health issues)
11Urinary retention
alternatives
1Cetirizine (Zyrtec)
2Loratadine (Claritin)
3Fexofenadine (Allegra)
4Levocetirizine (Xyzal)
contraindications
1Known hypersensitivity or allergy to diphenhydramine or related compounds
2Severe liver or kidney disease
3Angle-closure glaucoma
4Prostatic hypertrophy
5Severe respiratory insufficiency
interactions
1Alcohol
2Other central nervous system depressants (e.g., opioids, benzodiazepines)
3MAOIs
4Anticholinergic medications
5Other medications that can cause drowsiness or sedation
warnings and precautions
1May impair mental alertness and motor skills.
2Use with caution in patients with asthma or other respiratory conditions, as it may worsen symptoms.
3Avoid driving or operating machinery after taking the medication.
4Use with caution in patients with a history of cardiovascular disease or seizures.
5Consult a doctor if symptoms persist or worsen.
additional information
patient specific considerations
ageBenadryl is generally safe for use in a 25-year-old male, but dosage and use should be guided by a healthcare professional.
weightDosage should be adjusted according to individual needs and response; a healthcare provider can provide personalized guidance.
other factorsPre-existing health conditions, other medications or supplements being taken are all factors in deciding the safest dosage and usage.
special notesThis information is for educational purposes only and should not be considered medical advice. Always consult with a healthcare professional for any health concerns or before making any decisions related to your health or treatment.

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Reference Patient:(25 years,Male, 70KGs) *Not a medical advice

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