| name | Capsaicin |
| classification | Topical analgesic, local irritant |
| pharmacokinetics | Capsaicin is primarily absorbed through the skin and mucous membranes. It acts locally by depleting substance P, a neurotransmitter involved in pain transmission. Systemic absorption is minimal but can occur with significant skin damage or ingestion. |
| suggested dosage | Dosage varies significantly depending on product form and indication. Always follow specific instructions on the product label and/or as prescribed by a healthcare professional. Topical capsaicin products come in various concentrations (e.g., 0.025%, 0.05%, 0.075%, 0.08%) and application frequencies. Ingestion is not recommended and can be dangerous. |
| indications | Topical use for treating neuropathic pain (e.g., post-herpetic neuralgia, diabetic neuropathy, osteoarthritis pain) and other chronic pain conditions. |
| safety in pregnancy | Limited human data. Should not be used during pregnancy unless potential benefits outweigh risks. Consult a healthcare professional. |
| safety in breastfeeding | Limited data. Not recommended during breastfeeding due to potential absorption and transfer into breast milk. |
| side effects | | 1 | Burning sensation (local) | | 2 | Skin irritation | | 3 | Erythema (redness) | | 4 | Pruritus (itching) | | 5 | Local pain and discomfort | | 6 | Rarely, allergic reactions |
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| alternatives | |
| contraindications | | 1 | Hypersensitivity to capsaicin | | 2 | Open wounds or broken skin in application area | | 3 | Children (safety and efficacy not established) | | 4 | Active skin infections (application not generally recommended to affected areas) | | 5 | Ingestion |
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| interactions | Limited clinical data. Possible interactions with other topical or systemic medications. Exercise caution when combining with other treatments. |
| warnings and precautions | | 1 | Avoid contact with eyes and mucous membranes. | | 2 | Apply a thin layer to the affected area only. | | 3 | Wash hands thoroughly after application. | | 4 | Monitor for and manage any adverse reactions. | | 5 | If significant skin irritation develops, discontinue use and contact a healthcare professional. | | 6 | Never ingest capsaicin. |
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| additional informations | Proper handling and application are crucial to minimize adverse effects. Consult with a healthcare professional for personalized advice. |
| patient specific notes | For a 25-year-old male weighing 70 kg, topical capsaicin use should follow product instructions and be supervised by a healthcare professional. Consult your doctor to determine appropriateness and potential dosage modifications based on individual needs and condition. |
