| drug | Cephradine |
| name | Cephradine |
| classification | First-generation cephalosporin antibiotic |
| pharmacokinetics | | absorption | Well absorbed orally, but absorption may be reduced by food. Peak plasma levels are reached within 1-2 hours. | | distribution | Distributed throughout the body, including the kidneys, liver, and lungs. Penetration into the cerebrospinal fluid is limited. | | metabolism | Metabolized primarily in the liver. | | excretion | Excreted primarily by the kidneys as unchanged drug; dosage adjustments may be necessary in patients with renal impairment. |
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| suggested dosage | | oral | 250mg-500mg every 6 hours | | Note | Specific dosage should be determined based on the severity of the infection, patient's kidney function, and individual response. |
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| indications | | 1 | Treatment of infections caused by susceptible Gram-positive and Gram-negative organisms, including skin infections, respiratory tract infections, urinary tract infections, and wound infections. |
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| safety in pregnancy | | category | B | | note | Limited data available; use during pregnancy only if the potential benefits outweigh the potential risks. |
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| safety in breastfeeding | | potential excretion | Cephradine is excreted in breast milk, but at a low level. Use caution if breastfeeding, and monitor for potential adverse effects. | | note | Consult with a physician before use. |
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| side effects | | 1 | Gastrointestinal upset (e.g., nausea, vomiting, diarrhea) | | 2 | Allergic reactions (e.g., rash, hives, itching, anaphylaxis) | | 3 | Headache | | 4 | Superinfection (e.g., yeast or fungal infections) | | 5 | Diarrhea and nausea may be more pronounced with higher doses or in patients with pre-existing intestinal or stomach problems |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to cephalosporins or penicillins (cross-allergenicity is a concern) | | 2 | Severe renal impairment requiring dialysis |
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| interactions | | 1 | May increase the effect of anticoagulants | | 2 | May decrease the effect of oral contraceptives | | 3 | May interact with other medications; consult with a doctor or pharmacist for potential interactions |
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| warnings and precautions | | 1 | Monitor for signs of allergic reactions | | 2 | Monitor for signs of superinfections | | 3 | Use cautiously in patients with renal impairment | | 4 | Dosage adjustments may be necessary in patients with hepatic impairment | | 5 | May cause false-positive results in certain urine tests |
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| additional informations | | important notes | Cephradine is a first-generation cephalosporin, so its effectiveness against specific infections may vary. Susceptibility testing of the causative organism should be considered when making treatment decisions. | | administration details | Administered orally or intravenously. Oral administration is typically preferred for uncomplicated infections. | | patient education | Advise patients to complete the entire course of treatment, even if symptoms resolve, to prevent recurrence and development of resistant bacteria. |
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| patient specific considerations | | age | Not applicable | | weight | Not applicable (dosage is generally adjusted by renal function) | | sex | Not applicable |
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| disclaimer | This information is for educational purposes only and does not constitute medical advice. Consult a healthcare professional for any health concerns or before making any decisions related to your health or treatment. |
