| name | Clobetasol Propionate Ointment |
| Classification | Topical Glucocorticoid |
| Pharmacokinetics | Clobetasol propionate is a potent topical corticosteroid that is readily absorbed through the skin. It exerts its anti-inflammatory effects locally. Systemic absorption is generally low, but can be increased with extensive application, prolonged use, or compromised skin barrier. Metabolism occurs primarily in the liver, and the drug is eliminated primarily through the biliary pathway. |
| suggested dosage | Apply a thin layer of ointment to the affected area once or twice daily, as directed by a physician. The duration of treatment should be determined by the physician and is generally short-term to avoid potential side effects. |
| indications | Clobetasol propionate ointment is indicated for the treatment of inflammatory skin conditions, such as:
* Atopic dermatitis
* Contact dermatitis
* Seborrheic dermatitis
* Psoriasis (in limited areas)
* Eczema
* Dermatitis, including allergic and irritant dermatitis
* Various inflammatory skin rashes and localized skin conditions |
| safety in pregnancy | Use during pregnancy should be avoided unless clearly necessary by a physician, weighing the potential benefits against possible risks to the developing fetus. Limited data exists and more research is needed. |
| safety in breastfeeding | Use should be avoided if possible during breastfeeding. If used, a physician should carefully evaluate benefits versus risks and choose the lowest effective dose. |
| side effects | | 1 | Skin thinning (atrophy) | | 2 | Skin discoloration | | 3 | Striae (stretch marks) | | 4 | Telangiectasia (small dilated blood vessels) | | 5 | Purpura (bruising) | | 6 | Burning or stinging sensation at application site | | 7 | Acne or folliculitis | | 8 | Local skin infections | | 9 | Systemic effects (rare but potential): | | 10 | Cushing's syndrome (with extensive or prolonged use) |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity or allergy to clobetasol propionate or any of its components. | | 2 | Active skin infection at the application site. |
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| interactions | Limited interaction data exists, but caution is advised when using with other topical medications. Consult with a physician regarding concomitant use. |
| warnings and precautions | | 1 | Avoid use on large areas of the skin, or for prolonged periods to reduce risk of systemic side effects. | | 2 | Do not use over open wounds or broken skin. | | 3 | Do not use occlusive dressings with this topical medication unless directed by your physician. | | 4 | Patients with a history of skin infections should use with caution. | | 5 | Monitor for signs of skin atrophy, or systemic effects. | | 6 | Discontinue use if any significant irritation or adverse reactions develop. | | 7 | Use cautiously in children, and always under the supervision of a physician, especially if the child has a history of skin conditions or significant skin exposure. |
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| additional informations | This information is for educational purposes only and should not be considered medical advice. Always consult with a healthcare professional before starting any new medication or treatment plan. Dosage and treatment duration are determined by a physician based on individual patient needs. |
| patient specific details | |
