name | Clobetasol Propionate Topical |
Classification | Corticosteroid, Topical |
Pharmacokinetics | Clobetasol propionate is a potent corticosteroid that is readily absorbed through the skin. The precise pharmacokinetic parameters are not well characterized for topical application as compared to systemic use, but it's largely dependent on the concentration of the topical formulation, the site and extent of application, and the individual's skin condition. The primary action is local and within the skin, with very little systemic absorption. However, prolonged or extensive use may lead to systemic effects. |
suggested dosage | Dosage is dependent on the specific condition and formulation. Refer to the package insert for complete details. Typically, apply a thin layer of the ointment or cream to the affected area once or twice daily. Avoid frequent or prolonged use to reduce risk of skin atrophy, striae, and other side effects. |
indications | Clobetasol propionate topical is used to treat various inflammatory skin conditions, including psoriasis, eczema, dermatitis, and other skin reactions. It is also useful for reducing inflammation related to allergic contact dermatitis and certain skin infections. It is important to consult with a physician about appropriate use and duration of treatment for particular conditions. |
Safety in pregnancy | Clobetasol propionate topical should be used during pregnancy only when clearly needed and under direct medical supervision. Limited human data exists. Avoid extensive use in pregnancy. The potential risks to the fetus need to be carefully considered in consultation with a physician. The benefits of treatment must outweigh the potential risks. No conclusive information exists about potential teratogenicity or long-term developmental effects. |
Safety in breastfeeding | Clobetasol propionate topical should be used cautiously during breastfeeding. Limited data exists, but the potential for systemic absorption and transfer to the infant is considered to be low. Use in breast-feeding mothers should only be considered with careful consideration of potential risks and benefits in consultation with a physician. |
side effects | 1 | Skin irritation | 2 | Burning sensation | 3 | Skin thinning (atrophy) | 4 | Striae (stretch marks) | 5 | Skin dryness | 6 | Skin discoloration | 7 | Hirsutism (excessive hair growth) | 8 | Increased skin fragility | 9 | Infections (superficial) | 10 | Acne | 11 | Purpura (skin bruising) |
|
alternatives | |
contraindications | 1 | Known hypersensitivity to clobetasol or other corticosteroids | 2 | Uncontrolled infections (skin) | 3 | Active skin ulcers or lesions that are not healing | 4 | Use over large areas of skin for prolonged periods (unless under medical supervision). | 5 | Use over the face and eye area (unless under medical supervision). |
|
interactions | Limited interactions are expected with topical use, but potentially interact with other topical medications. Consult a physician if using other topical products. There is no known significant interaction with oral medications. |
warnings and precautions | 1 | Use only as directed by a physician. | 2 | Avoid contact with eyes and mucous membranes. | 3 | Discontinue use if irritation or other adverse effects develop. | 4 | Do not use on open wounds or skin abrasions. | 5 | Monitor treatment response regularly. | 6 | Potential for systemic effects with prolonged or extensive use. | 7 | Use with caution in patients with a history of skin thinning or other skin conditions that may be exacerbated by steroids. | 8 | Inform your physician of all medications and supplements you are taking. |
|
additional information | This information is for general knowledge and informational purposes only, and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment. |
patient profile | |