| name | Differin (Adapalene) |
| Classification | Retinoid, Topical |
| Pharmacokinetics | Adapalene is a topical retinoid that is primarily absorbed through the skin. It is metabolized in the skin and liver. The extent of systemic absorption is low, but some systemic effects can occur. The elimination half-life is about 3-6 hours. |
| suggested dosage | | male 25 70kg | Topical application once daily at bedtime. Initial treatment may start with a 0.1% concentration, gradually increasing to 0.3% or 0.1% twice daily, depending on skin tolerance. Consult a dermatologist for specific dosage recommendations. | | important note | Dosage is tailored to individual patient response and should be guided by a healthcare professional. |
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| indications | Treatment of acne vulgaris (mild to moderate). May also be used to treat acne scars, keratosis pilaris, and other skin conditions. |
| Safety in pregnancy | Pregnancy category C. Adapalene should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Limited data are available on the use of adapalene during pregnancy. Avoid use during pregnancy if possible. |
| Safety in breastfeeding | Limited data available regarding adapalene use in breastfeeding mothers. Consider the potential benefits and risks with a healthcare professional before use. |
| side effects | | 1 | Dryness, irritation, redness, peeling, burning, or stinging of the skin | | 2 | Papules, pustules, or other acne flare-ups (initial use) | | 3 | Excessive sun sensitivity (avoid direct sun exposure) | | 4 | Rarely: Skin rash, allergic reactions, or other systemic effects (usually related to higher systemic absorption) |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity or allergy to adapalene or other retinoids | | 2 | Severe skin conditions or irritation | | 3 | Skin conditions that are currently worsening | | 4 | Use with strong immunosuppressant medications (discuss with doctor) |
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| interactions | | 1 | May increase the skin's sensitivity to sunlight, requiring increased sun protection measures | | 2 | Concurrent use of other topical acne medications, like benzoyl peroxide or salicylic acid, can increase the risk of skin irritation. Use cautiously and monitor closely. | | 3 | May increase the absorption of other topical medications. Consult your healthcare provider about any co-medications. | | 4 | Avoid use with highly irritating skincare products. |
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| warnings and precautions | | 1 | Start with a low dosage and gradually increase as tolerated, monitoring for skin reactions | | 2 | Use a moisturizer to manage skin dryness | | 3 | Avoid prolonged sun exposure and use sunscreen with a high SPF | | 4 | Do not use on broken or irritated skin | | 5 | Inform your doctor about any other medical conditions or medications you are taking. | | 6 | Discontinue use and consult a doctor if the skin reaction is severe or persistent. |
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| additional information | | 1 | Differin is available in different concentrations. Always follow the prescription instructions. | | 2 | Proper skin care regimen is crucial for maximizing treatment efficacy and minimizing side effects. | | 3 | Consistent use is important for optimal results. Don't expect immediate results. | | 4 | This information is not a substitute for professional medical advice. Always consult a dermatologist or healthcare professional before starting any new medication or treatment. |
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