| name | Doxycycline |
| classification | Tetracycline antibiotic |
| pharmacokinetics | Doxycycline is readily absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved within 2-4 hours after oral administration. It is highly tissue and cellular distributed. Excretion is primarily renal, with a half-life of approximately 16-22 hours. The drug can accumulate in tissues and organs such as teeth and bones. |
| suggested dosage | | general | Dosing depends on the specific indication and the patient's condition. Consult a physician for appropriate dosage. | | example for acne | | age 25 weight 70kg | Typical oral dosage for acne vulgaris is 100mg twice daily for adults (this is a starting point, and dosage may need to be adjusted based on individual response and severity). | | example for other indications | For other indications, appropriate dosage varies depending on severity and the specific bacterial infection. Consult a physician. |
|
|
| indications | | 1 | Acne vulgaris | | 2 | Chlamydia trachomatis infection | | 3 | Lyme disease | | 4 | Bacterial pneumonia | | 5 | Other bacterial infections |
|
| safety in pregnancy | Doxycycline is a category D drug during pregnancy. It may cause fetal harm. Use only when the potential benefits outweigh the risks, and under close medical supervision. |
| safety in breastfeeding | Doxycycline is excreted in breast milk. Avoid use during breastfeeding, unless the benefits clearly outweigh the potential risks to the infant. |
| side effects | | 1 | Nausea | | 2 | Vomiting | | 3 | Diarrhea | | 4 | Gastrointestinal upset (e.g., abdominal pain) | | 5 | Headache | | 6 | Photosensitivity (increased risk of sunburn) | | 7 | Vaginal candidiasis | | 8 | Tooth discoloration in children and adolescents (especially if given during tooth development) | | 9 | Rash | | 10 | Liver function changes | | 11 | Increased risk of fungal superinfections |
|
| alternatives | |
| contraindications | | 1 | Known hypersensitivity to tetracyclines or any of its components | | 2 | Severe liver disease | | 3 | Severe renal disease | | 4 | Pregnant women unless benefits outweigh risks | | 5 | Lactating women unless benefits outweigh risks | | 6 | Children with developing teeth or developing bones (due to discoloration risk) |
|
| interactions | | 1 | Antacids (reduce absorption) | | 2 | Aluminum and magnesium containing antacids or medications | | 3 | Iron supplements (reduce absorption) | | 4 | Certain medications used to lower stomach acid (reduce absorption) | | 5 | Other drugs that can affect liver or kidney function | | 6 | Oral contraceptives (may reduce effectiveness) |
|
| warnings and precautions | | 1 | Sunlight sensitivity, use sunscreen or avoid sun exposure | | 2 | Monitor liver and kidney function (especially if used long-term or in higher doses) | | 3 | May cause discoloration of developing teeth in children | | 4 | May increase risk of superinfections | | 5 | Potential for gastrointestinal disturbances, so it is important to take with food or milk to reduce stomach upset | | 6 | Do not use in children under 8 years of age except when prescribed specifically for a particular indication and under supervision of a qualified physician. |
|
| additional informations | Always take doxycycline as directed by your physician. Do not stop taking the drug without consulting your doctor. It is important to complete the entire course of treatment, even if symptoms improve, to prevent recurrence and the development of antibiotic resistance. Store at room temperature. |
| patient profile | |
