| name | Emetine |
| Classification | Anti-emetic, anti-amoebic |
| Pharmacokinetics | | absorption | Poorly absorbed orally; given intravenously or intramuscularly. | | distribution | Widely distributed, including the brain, liver, and kidneys. Concentrates in amoebic lesions. | | metabolism | Metabolized primarily by the liver; metabolites are excreted in the urine and bile. | | elimination | Elimination half-life is prolonged, particularly in patients with hepatic or renal dysfunction. |
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| suggested dosage | | note | Dosage and duration of therapy are determined by the physician based on the severity of the amoebic infection and individual patient response. | | adult IV | Initial dose typically 1 mg/kg body weight IV, then 0.25-1mg/kg, administered every 8 hours for 2 to 6 days. Dosage and course of therapy are optimized by your medical doctor. | | important note | This is a general guideline; precise dosages depend on factors such as patient weight and condition. **Always follow the prescription from your doctor.** |
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| indications | Treatment of amoebic dysentery and other amoebic infections. |
| safety in pregnancy | **Contraindicated.** Emetine has significant teratogenic potential. Use in pregnancy is strictly prohibited. |
| safety in breastfeeding | **Contraindicated.** Emetine is excreted in breast milk. Avoid breastfeeding during therapy. |
| side effects | | 1 | Nausea, vomiting | | 2 | Diarrhea | | 3 | Cardiac arrhythmias (most serious potential side effect) | | 4 | Myocardial depression | | 5 | Peripheral neuropathy | | 6 | Anorexia | | 7 | Fatigue | | 8 | Constipation | | 9 | Hepatotoxicity | | 10 | Renal toxicity |
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| alternatives | |
| contraindications | | 1 | Pregnant or breastfeeding women. | | 2 | Patients with severe cardiac disease. | | 3 | Patients with known hypersensitivity to emetine or other components of the formulation. | | 4 | Severe hepatic or renal impairment. |
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| interactions | | 1 | May enhance the effects of other medications that affect the cardiovascular system or the kidneys. | | 2 | Concurrent use with certain medications should be avoided or carefully monitored due to additive toxicity. | | 3 | Specific interaction details should be discussed with the treating physician. |
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| warnings and precautions | | 1 | Emetine is a potent medication and needs to be administered under medical supervision. Careful monitoring of cardiac function and other vital signs is crucial. | | 2 | Dosage must be carefully adjusted in patients with renal or hepatic dysfunction. | | 3 | Monitor for signs of cardiotoxicity during and after treatment. |
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| additional informations | | 1 | Emetine is a potent, potentially toxic drug, reserved for severe amoebiasis cases where other therapies are ineffective or contraindicated. | | 2 | Treatment course, dosing, and monitoring are critical aspects to ensure patient safety. | | 3 | Emetine use is significantly less common than other amoebiasis treatments due to safety concerns, particularly cardiac complications. | | 4 | Always seek medical advice before taking Emetine. |
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| patient specific notes | | age and weight | Patient is 25 years old and weighs 70 kg. This information is relevant for dosage calculation and potential adjustments to standard dosage. | | important note | The detailed information provided here is for general knowledge and should not be substituted for advice from a qualified healthcare professional. Specific medical guidance should be sought from the prescribing physician. |
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