| name | Fluticasone Propionate/Salmeterol (combination inhaler) |
| classification | Combination inhaled corticosteroid and long-acting beta2-agonist (LABA) for asthma and COPD |
| pharmacokinetics | Fluticasone propionate and salmeterol are absorbed in the lungs, with fluticasone exerting anti-inflammatory effects and salmeterol relaxing bronchial smooth muscles. Individual pharmacokinetic responses vary based on factors including lung function, age, kidney/liver function, and drug interactions. Absorption, distribution, metabolism, and excretion patterns are influenced by formulation and administration route. Specific details like half-life and bioavailability are not typically provided for combination inhalers but are often discussed in individual component monographs. |
| dosage | Dosage is patient-specific and must be determined by a healthcare professional. The specific dose, frequency, and duration depend on the severity and type of respiratory condition. Correct inhaler technique is crucial for proper medication delivery. |
| indications | Treating asthma and COPD when these conditions cannot be adequately controlled by a single medication. Symptoms include wheezing, shortness of breath, chest tightness, and coughing. |
| safety pregnancy | Limited data available. Use only when clearly necessary under healthcare professional supervision. Potential risks and benefits must be carefully evaluated. Discuss with your doctor. |
| safety breastfeeding | Limited data available. Use only when clearly necessary under healthcare professional supervision. Potential risks and benefits must be carefully evaluated. Discuss with your doctor. |
| side effects | | 1 | cough | | 2 | throat irritation | | 3 | headache | | 4 | hoarseness | | 5 | nausea | | 6 | increased risk of oral thrush | | 7 | muscle pain | | 8 | tremor | | 9 | changes in heart rate | | 10 | hypertension | | 11 | insomnia | | 12 | anxiety | | 13 | dizziness | | 14 | gastrointestinal disturbances (e.g., abdominal pain, diarrhea) | | 15 | hypersensitivity reactions (e.g., rash, hives, itching) | | 16 | adrenal insufficiency (in severe or prolonged use) |
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| alternative treatments | | 1 | Other inhaled corticosteroids (e.g., budesonide/formoterol) | | 2 | Other long-acting beta2-agonists (e.g., formoterol) | | 3 | Other combination inhalers | | 4 | Consideration of oral medications for severe cases |
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| contraindications | | 1 | Known hypersensitivity to fluticasone propionate, salmeterol, or other components | | 2 | Severe heart conditions (e.g., unstable angina, recent myocardial infarction) | | 3 | Severe uncontrolled hypertension |
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| drug interactions | Potential interactions with other medications, including other respiratory medications and some oral medications. Consult a doctor for any medication regimen. |
| warnings precautions | | 1 | Use inhaler precisely as prescribed. | | 2 | Do not increase the dose without consulting a doctor. | | 3 | Patients with pre-existing heart conditions should consult with their doctor for risk assessment. | | 4 | Monitor blood pressure, especially in patients with hypertension. | | 5 | Regular lung function monitoring. | | 6 | Regular follow-up with a physician. | | 7 | Caution in patients with history of psychosis or anxiety. | | 8 | Not suitable for all patients; discuss options with your doctor. |
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| additional information | Patient age and weight are factors considered in treatment decisions, but dosage should not be determined by these factors alone. Always consult with a healthcare professional. |
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