| name | ICS/LABA Combination Inhaler (Generic example: Fluticasone/Salmeterol) |
| classification | Long-acting bronchodilators and inhaled corticosteroids for COPD and Asthma |
| pharmacokinetics | | absorption | Systemic absorption of corticosteroids is minimized with inhaled delivery. LABA absorption depends on the specific drug, but rapid onset of action is seen in the lungs. | | distribution | Corticosteroids are distributed throughout the body. LABA primarily acts on the lungs. | | metabolism | Metabolism of both components varies, mainly in the liver. | | excretion | Excretion pathways depend on the specific drug, typically through urine and feces. |
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| suggested dosage | | general note | Dosage varies significantly based on individual needs and severity of condition. Always consult a doctor. | | example | 200 mcg Fluticasone/50 mcg Salmeterol twice daily as a starting dose. Adjustment will likely be made by the prescribing physician. | | important note | Adjusting the dose of inhaled medications can be tricky. A patient should closely monitor the impact of medication and report any changes to their health care provider. |
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| indications | | 1 | Management of asthma | | 2 | Prevention of asthma exacerbations | | 3 | Management of chronic obstructive pulmonary disease (COPD) | | 4 | Treatment of chronic bronchitis. |
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| safety in pregnancy | | summary | ICS/LABA combinations are generally used in pregnancy, but the potential risks of the corticosteroid component should be carefully considered by the doctor. | | additional notes | If used during pregnancy, the lowest effective dose should be used for as short a duration as possible. Consult the prescribing doctor immediately about the risks and benefits. |
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| safety in breastfeeding | | summary | Limited data exists on the safety of ICS/LABA in breastfeeding. Potential risks should be weighed against potential benefits. | | additional notes | Consult the prescribing doctor about risks to infant. |
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| side effects | | 1 | Oral candidiasis (thrush) | | 2 | Headache | | 3 | Cough | | 4 | Tremor (from LABA) | | 5 | Muscle cramps | | 6 | Insomnia (from LABA) | | 7 | Increased risk of cataracts and glaucoma (long-term use) | | 8 | Systemic effects of corticosteroids (e.g. osteoporosis, adrenal insufficiency if used for long-time) | | 9 | Very rare: serious allergic reactions, pneumonia |
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| alternatives | |
| contraindications | | 1 | Hypersensitivity to any component of the medication | | 2 | Severe impairment of liver or kidney function | | 3 | Uncontrolled systemic infections. |
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| interactions | | 1 | Other inhaled or oral corticosteroids | | 2 | Other medications that impact liver enzymes | | 3 | Certain medications that interact with beta-agonists |
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| warnings and precautions | | 1 | Use cautiously in patients with heart conditions, and diabetes. | | 2 | Regular monitoring of blood pressure and blood sugar levels may be necessary | | 3 | Patients should be instructed to rinse their mouth after use | | 4 | Instruct patients to carry an EpiPen or similar if they are prone to allergies |
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| additional informations | | important note | The provided information is for general knowledge only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting or changing any medication. | | patient factors | The patient's age, weight and other factors are considered by the doctor when prescribing medication. A patient's individual needs must always be taken into account. |
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