| name | Implantable Etonogestrel Rods (Nexplanon) |
| classification | Long-acting reversible contraceptive (LARC) |
| pharmacokinetics | Etonogestrel is released slowly from the implant into the bloodstream. Blood levels are maintained at a steady state within the first 24 hours and are sustained throughout the implant's effective duration. The rate of release is consistent, leading to a relatively stable hormonal profile. Exact pharmacokinetic details are proprietary and not readily available publicly. |
| suggested dosage | A single rod is implanted subdermally in the upper arm. No traditional dosage applies; it is a single, long-acting implant. |
| indications | | 1 | Contraception | | 2 | Treatment of moderate to severe acne (off-label) |
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| safety in pregnancy | Contraindicated if pregnant. This is a contraceptive. |
| safety in breastfeeding | Etonogestrel is likely present in breast milk. Consult a healthcare provider if breastfeeding. |
| side effects | | 1 | Weight changes | | 2 | Mood changes | | 3 | Headache | | 4 | Breast tenderness | | 5 | Spotting/irregular bleeding | | 6 | Acne | | 7 | Abdominal pain | | 8 | Breast pain | | 9 | Nausea | | 10 | Fatigue | | 11 | Hirsutism | | 12 | Decreased libido | | 13 | Infection at the implant site |
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| contraindications | | 1 | Known hypersensitivity to etonogestrel or implant components | | 2 | History of blood clots (thromboembolic disease) | | 3 | Known liver disease | | 4 | Undiagnosed vaginal bleeding | | 5 | Pregnancy |
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| interactions | | 1 | Limited information on significant drug interactions. Consult a healthcare provider for detailed information. | | 2 | May potentially alter metabolism of other medications, but usually not a major concern with common medications. |
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| warnings and precautions | | 1 | Risk of blood clots (thromboembolism), especially in individuals with risk factors (smoking, obesity, family history). | | 2 | Caution in patients with a history of or risk factors for cardiovascular disease. | | 3 | Regular check-ups recommended to monitor for side effects and address concerns. |
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| alternatives | |
| additional information | | 1 | High efficacy and low failure rate. | | 2 | Convenient and effective contraception for up to 3 years (individual variations). | | 3 | Placement by trained professional; thorough discussion advised before implantation. | | 4 | Effectiveness of Nexplanon for acne (off-label) is less extensively studied. | | 5 | Implant removal possible at any time; fertility generally returns quickly. |
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| patient specific considerations | | age | | | weight | | | additional medical history | | | other medications | |
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