| name | Nexplanon (etonogestrel implant) |
| Classification | Long-acting reversible contraceptive (LARC) |
| Pharmacokinetics | Etonogestrel is a progestogen that is released slowly from the implant into the bloodstream. The implant provides continuous low-dose hormone levels. Plasma concentrations of etonogestrel peak approximately 2–3 months after insertion and then remain relatively stable. The duration of action depends on the individual. |
| suggested dosage | A single implant is inserted subdermally, typically in the upper arm. No daily or periodic dosage is required. |
| indications | Prevention of pregnancy. |
| Safety in pregnancy | Nexplanon is **contraindicated** during pregnancy. If a patient becomes pregnant while using Nexplanon, the implant should be removed as soon as possible. Pregnancy should be suspected if the user misses a period. |
| Safety in breastfeeding | Nexplanon is generally considered safe during breastfeeding, although some studies suggest a possible decrease in milk production in some cases. Consult a healthcare provider. |
| side effects | | 1 | Irregular bleeding patterns (including amenorrhea or prolonged bleeding) | | 2 | Weight fluctuations | | 3 | Mood changes | | 4 | Headache | | 5 | Breast tenderness | | 6 | Acne | | 7 | Nausea | | 8 | Pain at the insertion site | | 9 | Infection or granuloma formation at the implant site | | 10 | Hair growth changes | | 11 | Possible decrease in milk production (if breastfeeding) | | 12 | Systemic effects like fatigue, dizziness, and abdominal discomfort are possible, although less frequent. |
|
| alternatives | | 1 | Other LARC methods such as the copper IUD, other hormonal IUDs, and other implantable contraceptives. Patient-specific factors (medical history, individual preferences) will guide which alternative is most appropriate. | | 2 | Barrier methods (condoms, diaphragms). |
|
| contraindications | | 1 | Known or suspected pregnancy | | 2 | History of blood clots (thromboembolic disorders) | | 3 | Known or suspected liver disease | | 4 | Severe undiagnosed vaginal bleeding | | 5 | Allergy to etonogestrel or other components of the implant | | 6 | Certain rare diseases. |
|
| interactions | | 1 | There are no significant drug interactions reported with Nexplanon. However, a healthcare provider should be informed of all medications and supplements taken. |
|
| warnings and precautions | | 1 | Close follow-up with a healthcare provider is recommended, especially during the first few months of use to monitor for changes in menstrual bleeding patterns. | | 2 | The effectiveness of Nexplanon, like other contraceptives, is dependent on proper use and insertion. Risks of pregnancy exist if the device is not placed or maintained properly. | | 3 | Users should be advised to immediately seek medical help if they experience severe side effects, such as severe pain, swelling, or redness at the implant site. | | 4 | Nexplanon does not protect against sexually transmitted infections (STIs). | | 5 | It is not intended to be used for emergency contraception. |
|
| additional informations | | 1 | Nexplanon typically provides highly effective contraception for up to 3 years. | | 2 | It is important to discuss potential risks and benefits with a healthcare professional before deciding if Nexplanon is the right choice. | | 3 | Removal of the implant is possible at any time if desired. |
|
| patient specific considerations | | age | 25 years (no specific concerns for this age group) | | weight | 70 kg (no specific concerns for this weight) |
|
