| drug | Tetracycline |
| classification | Tetracycline Antibiotic |
| pharmacokinetics | | absorption | Variable; absorption is enhanced by an empty stomach. Food and antacids reduce absorption. Peak serum concentrations typically occur 1-3 hours after oral administration. | | distribution | Distributes widely throughout the body, including tissues and fluids. Concentrations in the tissues and fluids usually exceed serum concentration. | | metabolism | Metabolized in the liver. Metabolites are excreted primarily in the urine and bile. | | excretion | Primarily through renal excretion as unchanged drug and metabolites. |
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| suggested dosage | | adult | Typically 250-500 mg every 6 hours, or as directed by a physician. Dosage and frequency may vary based on the specific infection and its severity. | | notes | Dosage should be adjusted based on individual patient factors (kidney function, liver function, etc.). Take the drug exactly as prescribed, with or without food, unless directed otherwise by a healthcare professional. |
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| indications | | 1 | Bacterial skin infections (e.g., cellulitis, impetigo) | | 2 | Bacterial infections of soft tissues (e.g., wound infections) | | 3 | Urinary tract infections (UTIs) caused by susceptible organisms | | 4 | Chlamydia trachomatis infections | | 5 | Syphilis (early stages) | | 6 | Acne vulgaris (moderate to severe) | | 7 | Typhoid fever | | 8 | Other bacterial infections, as determined by a physician |
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| safety in pregnancy | Tetracycline can cross the placenta and potentially harm the developing fetus. Use is generally not recommended during pregnancy, especially in the first trimester, unless the potential benefits clearly outweigh the risks, as determined by a healthcare professional. |
| safety in breastfeeding | Tetracycline may be present in breast milk. Use is not typically recommended during breastfeeding unless the potential benefits clearly outweigh the potential risks, as determined by a healthcare professional. |
| side effects | | 1 | Gastrointestinal upset (nausea, vomiting, diarrhea) | | 2 | Discoloration of permanent teeth (particularly in children) | | 3 | Photosensitivity (increased skin sensitivity to sunlight) | | 4 | Headache | | 5 | Vaginitis | | 6 | Superinfections (opportunistic fungal or bacterial infections) | | 7 | Allergic reactions (rash, hives, itching, difficulty breathing, anaphylaxis) | | 8 | Liver damage (rare) | | 9 | Pseudomembranous colitis (rare) |
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| alternatives | |
| contraindications | | 1 | Hypersensitivity or allergy to tetracycline or any of its components | | 2 | Pregnancy (unless benefits outweigh risks, as determined by a physician) | | 3 | Lactation (unless benefits outweigh risks, as determined by a physician) | | 4 | Severe liver or kidney disease | | 5 | Children under 8 years old (due to potential tooth discoloration) | | 6 | Patients with severe photosensitivity issues |
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| interactions | | 1 | Antacids and medications containing divalent or trivalent cations (e.g., calcium, magnesium, aluminum, iron) reduce tetracycline absorption. Administer these medications at least 2 hours apart. | | 2 | Drugs that affect liver function may increase the risk of side effects. Always inform your doctor about all medications you are taking. | | 3 | Certain medications may interact, including oral contraceptives and anticoagulants. Consult your doctor about potential interactions. |
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| warnings and precautions | | 1 | Take this medication exactly as prescribed by your physician. Do not adjust dosage without consulting your doctor. | | 2 | Patients with known liver or kidney disease, or those taking other medications, should inform their doctor. | | 3 | Report any changes in your health status or new medications to your physician. | | 4 | Contact a healthcare provider immediately for any signs of allergic reaction. | | 5 | Avoid prolonged sun exposure or use sunscreen when taking Tetracycline to minimize photosensitivity risk. | | 6 | Inform your doctor if you have a history of GI disorders or experience persistent GI distress. |
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| additional informations | Tetracycline is a valuable antibiotic, but it should be used appropriately to avoid resistance. Seek medical advice for diagnosis and appropriate treatment. |
| patient profile | |
