| name | Permethrin |
| Classification | Ectoparasiticidal, insecticide |
| Pharmacokinetics | Permethrin is primarily absorbed transdermally. It is highly lipophilic and readily penetrates the skin and other tissues. The drug is metabolized in the liver and eliminated primarily in the feces. The half-life varies based on the formulation, but generally ranges from 6 to 24 hours. |
| suggested dosage | Dosage depends on the specific product and condition being treated. Permethrin topical creams and lotions are typically applied as directed on the product label. It's crucial to follow the instructions carefully. Consult with a doctor for appropriate dosage recommendations. **Important Note:** This information is for general knowledge only and should not be used to self-treat. Always consult a healthcare professional for personalized dosage instructions. |
| indications | Permethrin is primarily used to treat scabies and head lice infestations. It works by paralyzing and killing the parasites. |
| Safety in pregnancy | Limited data are available on the safety of permethrin in pregnancy. Generally, it is considered reasonably safe during pregnancy when used as directed on the skin for lice or scabies. However, caution is warranted. Consult with a doctor before use during pregnancy. |
| Safety in breastfeeding | Limited data exists on permethrin safety in breastfeeding mothers. The drug may be passed to the infant through breast milk. Discuss with a doctor to weigh potential risks and benefits. |
| side effects | | 1 | Skin irritation (e.g., redness, itching, rash) | | 2 | Burning sensation | | 3 | Local allergic reactions | | 4 | Possible systemic absorption with potential for more significant side effects if absorbed through broken skin | | 5 | Rarely, more serious systemic effects (e.g., dizziness, headache, nausea, vomiting) but these are usually associated with significant skin absorption or misuse. Always follow the instructions for use. |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity or allergy to permethrin or any of its ingredients | | 2 | Use on broken or irritated skin | | 3 | Use on open wounds or lesions | | 4 | Use in children younger than 2 months old (unless specifically directed by a doctor) |
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| interactions | | 1 | Possible interactions with other medications or health conditions. Consult with a doctor about concurrent medications. |
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| warnings and precautions | | 1 | Always follow the directions on the product label. Apply only to the affected areas and avoid contact with eyes, mouth and other sensitive areas. | | 2 | Wash hands thoroughly after application. | | 3 | Clean and disinfect bedding, clothing, and towels to eliminate parasites. | | 4 | Ensure adequate ventilation if used in a confined space. | | 5 | Monitor for skin reactions and stop use if any irritation or rash is experienced. |
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| additional informations | | 1 | Available in various forms (lotion, cream, shampoo). | | 2 | Effective in killing lice and mites but may not prevent reinfection without thorough sanitation of bedding, clothing, and towels. | | 3 | Some formulations may be more irritant than others. | | 4 | If symptoms persist or worsen, seek medical advice. |
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| patient specific considerations | | age | 25 years old - generally not a contraindication for permethrin use, but always discuss with a doctor. | | weight | 70 kg - generally not a contraindication for permethrin use, but appropriate dosage should be followed. | | other information | The patient should be informed about the potential side effects and asked to report any unusual reaction to the medical professional. |
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