| name | Permethrin Topical |
| classification | Antiparasitic, Pyrethroid Insecticide |
| pharmacokinetics | Permethrin is readily absorbed through the skin. It acts primarily through a nerve cell membrane interaction, disrupting neuronal function in parasites, rather than a systemic effect. Metabolism is primarily hepatic, with elimination primarily through the biliary route. The topical application limits systemic exposure. |
| suggested dosage | For head lice: Apply a thin layer of permethrin cream to the scalp, paying close attention to the hair roots. Leave the cream on for 10 minutes. Then rinse thoroughly with water and shampoo hair. Repeat in 7-10 days. For body lice: Apply a thin layer to all areas of the body where lice are present. Leave on for 8-12 hours and wash off. Repeat in 7-10 days. Consult a doctor for specific guidance. Dosage may vary depending on the specific condition and severity. |
| indications | Treatment of head lice (Pediculosis capitis) and body lice (Pediculosis corporis). May also be used for scabies, though ivermectin is generally preferred. |
| safety in pregnancy | Permethrin is generally considered safe for use during pregnancy. However, it's crucial to follow the doctor's instructions and use the lowest effective dose for the shortest duration possible. Consult your physician. Limited data exists, so be cautious, especially in the first trimester. |
| safety in breastfeeding | Permethrin is generally considered safe for use while breastfeeding, but consult your healthcare professional before use. |
| side effects | | 1 | Skin irritation | | 2 | Dry skin | | 3 | Burning sensation | | 4 | Rash | | 5 | Pruritus (itching) | | 6 | Headache | | 7 | Transient mild stinging sensation (temporary) | | 8 | Rarely, allergic reactions like hives or swelling may occur. |
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| alternatives | |
| contraindications | | 1 | Known allergy to permethrin or other pyrethroids | | 2 | Severe skin conditions in the treated area |
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| interactions | Limited significant interactions are known. However, inform your doctor about all medications you are taking. |
| warnings and precautions | | 1 | Apply only as directed. Follow the specific instructions for head lice vs. body lice. | | 2 | Avoid contact with eyes. If contact occurs, flush with plenty of water. | | 3 | Do not use on broken skin, open wounds, or irritated skin. | | 4 | If symptoms worsen or persist, discontinue use and contact a healthcare professional. | | 5 | Use proper hand hygiene after application. | | 6 | Monitor for any signs of allergic reactions. |
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| additional informations | | 1 | Permethrin is typically very effective when used properly. | | 2 | Treatment should be complete to avoid reinfestation; follow all directions to ensure treatment efficacy. | | 3 | Consult a doctor for the correct diagnosis and treatment plan, particularly if there are multiple infestations. | | 4 | Children and adolescents may require special consideration when using this medication |
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| patient profile | | age | 25 years | | weight | 70 kg | | gender | male |
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