| name | Ticarcillin Clavulanate |
| classification | Penicillins, penicillinase-resistant; Antibacterial, broad-spectrum |
| pharmacokinetics | Ticarcillin is rapidly absorbed after intramuscular or intravenous administration. Clavulanate, a beta-lactamase inhibitor, enhances the activity of ticarcillin by preventing bacterial inactivation. The drug is distributed widely throughout the body and is excreted primarily by the kidneys. However, renal impairment may significantly alter the dosage requirements. |
| suggested dosage | | note | Dosage must be individualized based on factors such as infection severity, patient renal function, and response to treatment. | | adult | | 1 | | route | Intravenous | | typical dose | 3.1-12 g/day in divided doses, every 4-6 hours | | low dose | 6 g/day | | high dose | 12 g/day | | adjustments needed | in patients with renal impairment and adjust for infections with significant tissue involvement or abscess formation |
| | 2 | | route | Intramuscular | | typical dose | 3-6 g/day in divided doses, every 4-6 hours | | adjustments needed | in patients with renal impairment |
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| | pediatric | Dosage based on weight and specific condition. Consult drug prescribing information for details. Dosage is usually adjusted by an experienced medical professional. |
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| indications | Ticarcillin-clavulanate is indicated for the treatment of infections caused by susceptible bacteria, including those that produce beta-lactamases. Common indications include: Lower respiratory tract infections, skin and soft tissue infections, intra-abdominal infections, urinary tract infections, and others. |
| safety in pregnancy | Limited data exists on the use of ticarcillin-clavulanate in pregnancy. While it is often considered safe in this context, it must be evaluated carefully. Discuss possible risks and benefits with a physician, especially during the first trimester of pregnancy. Monitoring should be performed as deemed necessary. |
| safety in breastfeeding | Ticarcillin and clavulanate are excreted in breast milk. Infants may experience side effects, however, if they are to develop them, those are generally mild. Weigh benefits to the mother versus possible side effects for the infant. Consultation with a medical professional is recommended. |
| side effects | | 1 | Nausea, vomiting, diarrhea, abdominal pain, rash, allergic reactions (e.g., hives, swelling), headache, dizziness, and rarely, neutropenia, thrombocytopenia, and hepatitis. | | 2 | Severe allergic reactions (anaphylaxis) are possible but rare. |
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| alternatives | |
| contraindications | Patients with known hypersensitivity to penicillin or any component of the formulation. |
| interactions | May interact with other medications, including certain diuretics, anticonvulsants, and other antibiotics. Consult with a physician about possible interactions with other medications currently being taken. |
| warnings and precautions | | 1 | Monitor renal function, especially in patients with pre-existing kidney disease. | | 2 | Closely observe patients for signs of allergic reactions, including rash and difficulty breathing. | | 3 | Monitor blood counts (CBC) periodically during treatment. | | 4 | Avoid use in patients with a history of severe allergic reaction to penicillin. | | 5 | Dosage should be adjusted in patients with impaired renal function. | | 6 | Appropriate cultures should be obtained before initiation of antibiotic therapy. The results of the culture should dictate treatment decisions. |
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| additional informations | Patient age and weight are important factors when assessing dosage and potential risks. If the patient has any pre-existing conditions, this may affect the use of this drug and require physician consultation. This information is for educational purposes only and does not constitute medical advice. Consult a healthcare professional for any health concerns or before making any decisions related to your health or treatment. |
