| name | Vitamin D3 (Cholecalciferol) |
| Classification | Fat-soluble vitamin |
| Pharmacokinetics | Vitamin D3 is absorbed in the small intestine, primarily with dietary fats. It undergoes hydroxylation in the liver and kidneys to its active form, calcitriol. The half-life varies depending on the form and dose. It is stored in the liver and adipose tissue. |
| suggested dosage | | adult | The recommended dosage of vitamin D3 varies depending on the individual's needs and health status. Consult a physician for personalized recommendations. Common dosages range from 600 IU to 800 IU daily. | | special conditions | Patients with specific conditions like kidney disease or malabsorption syndromes may require higher or lower dosages, under medical supervision. |
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| indications | | 1 | Prevention and treatment of vitamin D deficiency | | 2 | Osteoporosis prevention and treatment | | 3 | Osteomalacia prevention and treatment | | 4 | Muscle weakness | | 5 | Increased risk of fractures | | 6 | Support calcium homeostasis |
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| safety in pregnancy | Vitamin D is generally considered safe during pregnancy in recommended doses. Adequate vitamin D levels are essential for fetal bone development and overall health. Consult a healthcare provider for guidance and dose adjustments. |
| safety in breastfeeding | Vitamin D is transferred to breast milk and generally considered safe in recommended amounts. Consult a healthcare provider for personalized recommendations to ensure appropriate intake for both mother and infant. |
| side effects | | 1 | Increased calcium levels (hypercalcemia) - may lead to nausea, vomiting, constipation, and excessive thirst. | | 2 | Kidney stones (due to high calcium levels) | | 3 | Headache | | 4 | Nausea | | 5 | Vomiting | | 6 | Loss of appetite | | 7 | Constipation |
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| alternatives | | 1 | Vitamin D2 (Ergocalciferol) | | 2 | Other vitamin supplements (calcium, magnesium) - in combination with vitamin D to address potential deficiencies. |
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| contraindications | | 1 | Hypercalcemia (high calcium levels) | | 2 | Hypervitaminosis D (excess vitamin D) | | 3 | Kidney stones (renal calculi) | | 4 | Severe kidney disease (renal impairment) - requires close medical monitoring. |
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| interactions | | 1 | Some medications (e.g., certain anti-seizure drugs, corticosteroids) may affect vitamin D metabolism. Consult a healthcare provider if taking any other medications. | | 2 | Drugs that bind to calcium (e.g., certain antibiotics, antacids) may affect vitamin D absorption. | | 3 | Excessive intake of calcium containing supplements - may increase the risk of side effects. |
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| warnings and precautions | | 1 | Vitamin D supplements should not be taken without consulting a doctor, especially when other medical conditions exist, or with concomitant use of other medications. | | 2 | Individuals with pre-existing kidney conditions should monitor vitamin D intake very carefully and under doctor's supervision. | | 3 | Do not exceed recommended dosages without medical advice. | | 4 | Monitoring of blood calcium levels may be necessary for patients receiving high doses. |
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| additional informations | Vitamin D supplementation should be tailored to the individual's specific needs. A blood test can determine if vitamin D levels are within the appropriate range. Dietary sources of vitamin D include fatty fish, egg yolks, and fortified foods. |
