name | Clobetasol |
Classification | Topical corticosteroid, potent |
Pharmacokinetics | Clobetasol propionate is a potent topical corticosteroid that is readily absorbed through the skin. It has a relatively short duration of action. The drug is primarily metabolized in the liver and excreted in the urine and feces. Specific pharmacokinetic data may vary based on the formulation and site of application. Systemic absorption is generally low with topical use, but can be increased with prolonged or extensive use, particularly on large surface areas. |
suggested dosage | Dosage varies based on the specific condition and location of application. Consult a dermatologist or physician for appropriate dosage recommendations. Typical usage involves applying a thin film of cream or ointment to the affected area once or twice daily. Do not apply more frequently or in greater amounts than prescribed, as this does not increase efficacy but may increase the risk of side effects. |
indications | 1 | Treatment of inflammatory and pruritic dermatoses such as plaque psoriasis, atopic dermatitis, and seborrheic dermatitis, as well as other inflammatory skin conditions. | 2 | Treatment of localized dermatological conditions such as contact dermatitis and lichen planus. |
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Safety in pregnancy | Clobetasol should be used during pregnancy only when the potential benefit justifies the potential risk to the fetus. Consult with your doctor about appropriate use. Systemic absorption is possible and not fully understood during pregnancy. Topical use is preferred to minimize systemic effects. |
Safety in breastfeeding | Clobetasol should be used with caution during breastfeeding, as there is a potential for systemic absorption and transfer to the infant. If used, apply only to small areas as directed and be cautious to avoid contact with the breast. |
side effects | 1 | Skin atrophy (thinning of the skin) | 2 | Telangiectasia (small, dilated blood vessels) | 3 | Striae (stretch marks) | 4 | Purpura (bruising) | 5 | Local skin reactions such as irritation, burning, itching, or rash | 6 | Systemic effects (if absorption is high, such as with prolonged or extensive use): These may include adrenal suppression, Cushing's syndrome, and other side effects related to glucocorticoid use. |
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alternatives | |
contraindications | 1 | Known hypersensitivity to clobetasol or other topical corticosteroids | 2 | Active or suspected fungal skin infections (use of antifungal medications may be necessary concurrently) | 3 | Use on damaged, broken, or infected skin. |
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interactions | 1 | May interact with other topical medications, requiring discussion with the prescribing physician. |
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warnings and precautions | 1 | Avoid prolonged or excessive use, especially on large areas of skin. The risk of systemic effects increases with increased exposure. | 2 | Do not use on the face or intertriginous areas (skin folds) without careful consideration and monitoring. | 3 | Monitor for signs of skin thinning and other adverse effects. Report any unusual or worsening symptoms immediately. | 4 | Use caution in patients with a history of skin disorders or conditions that might make them more prone to topical drug absorption. |
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additional information | Always follow the prescribed dosage and instructions from your healthcare provider. Clobetasol should be used only under the supervision of a qualified healthcare professional. This information is not a substitute for professional medical advice. |
patient information | age | 25 | weight | 70 | notes | Patient age and weight are factors in determining appropriate dosage and potential for systemic side effects. However, specific dosage regimens should be determined by a physician. |
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