| name | Fluticasone |
| Classification | Corticosteroid, inhaled |
| Pharmacokinetics | Fluticasone propionate is a potent corticosteroid that is primarily administered via inhalation. After inhalation, the drug is absorbed into the lungs and exerts its effect locally. Systemic absorption is relatively low, but some systemic effects can occur, particularly with higher doses or prolonged use. The drug is metabolized primarily in the liver, and the metabolites are excreted in urine and bile. The half-life varies depending on the formulation and route of administration. Inhaled fluticasone has a relatively rapid onset of action. Local effects are predominantly seen due to minimal systemic absorption. |
| suggested dosage | The dosage of fluticasone is highly dependent on the specific condition being treated and the patient's response. This information is not a substitute for professional medical advice. Always consult a doctor or pharmacist for personalized dosage recommendations. Typical inhaled fluticasone dosage for asthma varies. |
| indications | Fluticasone is primarily used to prevent and control symptoms of asthma and other respiratory conditions, like chronic obstructive pulmonary disease (COPD). It is also used to treat allergic rhinitis and nasal polyps. |
| safety in pregnancy | Fluticasone use during pregnancy should be carefully considered and managed by a physician. While there aren't large-scale, long-term studies specifically on fluticasone during pregnancy, available evidence suggests that the risk of adverse effects to the fetus is generally considered low when used as directed for inhaled therapy. However, it is crucial to discuss the potential risks and benefits with a healthcare professional. |
| safety in breastfeeding | Fluticasone may be excreted in breast milk. The amount, however, is usually low and is not expected to cause significant adverse effects in a nursing infant. The decision to use fluticasone during breastfeeding should be made in consultation with a healthcare provider weighing the potential benefits and risks for both the mother and the infant. |
| side effects | | 1 | Local oropharyngeal (mouth and throat) side effects such as oropharyngeal candidiasis (thrush). | | 2 | Headache. | | 3 | Hoarseness. | | 4 | Cough. | | 5 | Nasal irritation. | | 6 | Very rarely, systemic effects such as Cushing's syndrome, adrenal insufficiency (especially with prolonged or high doses). | | 7 | Hypersensitivity reactions. | | 8 | Other possible side effects that are rare or less common are available on the prescribing information. |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to fluticasone or other corticosteroid components. | | 2 | Patients with active or untreated systemic fungal infections of the respiratory tract. |
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| interactions | Fluticasone may interact with other medications, including other corticosteroids, immunosuppressants, and medications that may affect liver function. Consult your doctor about any medications you are currently taking. |
| warnings and precautions | It's essential to follow prescribed dosage instructions meticulously. Patients with underlying conditions like diabetes and osteoporosis should discuss fluticasone use with their physician. Use in children may have different considerations from those in adults. Fluticasone may mask the symptoms of an acute asthma attack. Monitor for signs of worsening symptoms despite the use of fluticasone. |
| additional informations | Always follow the instructions provided by your doctor and pharmacist. The information here is for general knowledge only and does not constitute medical advice. Proper monitoring and adjustment of the dose are crucial, especially for prolonged therapy. |
| patient profile | |
