| drug | Topical Antihistamines |
| name | e.g., Diphenhydramine, Hydrocortisone, Loratadine |
| Classification | Anti-inflammatory, Antipruritic |
| Pharmacokinetics | Topical antihistamines reduce itching and inflammation by blocking histamine receptors on the skin. Absorption into the bloodstream can occur, but is generally minimal compared to oral antihistamines. |
| suggested dosage | Follow product instructions, and start with the lowest strength possible. |
| indications | Treatment of allergic skin reactions, itching (pruritus), insect bites, and mild rashes or hives. |
| Safety in pregnancy | Generally considered safe when used topically as directed. However, consult with a doctor before using during pregnancy, especially in the first trimester. Avoid using potent formulations without consulting a healthcare provider. |
| Safety in breastfeeding | Limited data available; check with a healthcare provider before use, especially in the first few months after delivery. Use the lowest effective dose. |
| side effects | Skin irritation, allergic reactions, contact dermatitis, stinging, burning or rash are possible, particularly with higher concentrations. These should not be taken without consulting a doctor. |
| alternatives | |
| contraindications | Not applicable in the vast majority of cases, but individuals allergic to any ingredient should not use them. Do not use in cases of suspected severe skin infections, as antihistamines will not resolve the underlying cause. |
| interactions | Interactions with other topical medications are possible. Always inform your doctor about all medications and supplements you are taking. |
| warnings and precautions | Apply to affected areas only. Do not use on large areas of skin, or for extended periods without consulting a doctor. Avoid contact with eyes. Stop use and consult a doctor if irritation worsens or spreads. Avoid using on broken skin. |
| additional information | Different types of topical antihistamines have varying potency. Diphenhydramine is often considered the least potent. Hydrocortisone is often combined with other ingredients in creams. Always consult a doctor for diagnosis and treatment recommendations. Check with your doctor or pharmacist before use if you are taking any other medications. |
| patient specific considerations | Dosage and frequency recommendations are as noted above. Any questions regarding specific use should be directed to the physician. |
