| drug | Mupirocin |
| form | Topical |
| patient details | |
| classification | Antibacterial |
| pharmacokinetics | | absorption | Minimal systemic absorption after topical application, primarily due to skin barrier function and poor lipid solubility. Small amounts may enter systemic circulation, but generally considered safe. | | distribution | Concentrates at the site of application. | | metabolism | Primary metabolism in the skin via enzymatic degradation. | | excretion | Mostly via renal and biliary excretion, primarily as metabolites. | | half life | Short, mostly resolved within 24 hours following a dose. |
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| suggested dosage | | adult | Apply a thin film of the medication to the affected area 2-3 times daily or as directed by a physician. Generally, treat for at least 48-72 hours. | | children | Dosage should be adjusted based on the child's age, weight, and condition. Consult a physician. |
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| indications | | 1 | Treatment of superficial skin infections caused by susceptible Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pyogenes. | | 2 | Treatment of impetigo | | 3 | Treatment of minor skin lesions |
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| safety in pregnancy | Limited data available for use in pregnancy, but generally considered safe for topical use when used appropriately. Consult with a physician about use during pregnancy. |
| safety in breastfeeding | Generally considered safe for topical use. Minimal systemic absorption expected. Consult with a physician before use during breastfeeding, however. |
| side effects | | 1 | Local skin reactions such as redness, itching, burning, irritation, or rash. These are usually mild and transient. | | 2 | Less common: Allergic reactions (e.g., contact dermatitis). | | 3 | Very rare, but serious: systemic reactions, though unlikely with topical use. |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity or allergy to mupirocin. | | 2 | Use on large, open wounds with significant exposure of underlying tissue. |
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| interactions | | 1 | No significant known interactions with other medications when used topically in the recommended manner. |
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| warnings and precautions | | 1 | Avoid contact with the eyes. If contact occurs, rinse thoroughly with water. | | 2 | Discontinue use and consult a physician if the condition worsens or does not improve. | | 3 | Do not use on damaged, broken skin or over large areas of skin. | | 4 | If the rash spreads or worsens, discontinue use immediately and seek medical advice. |
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| additional information | | 1 | The affected area should be thoroughly cleaned before application of the medication. | | 2 | Apply a small amount to the affected area and gently spread evenly. | | 3 | Mupirocin should not be used for a longer duration than necessary due to concerns about antibiotic resistance | | 4 | Avoid scratching or irritating the affected area. |
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