| name | Fusidic Acid |
| classification | Antibiotic (specifically, a macrolide-like antibiotic) |
| pharmacokinetics | Fusidic acid is primarily absorbed from the gastrointestinal tract. Peak plasma concentrations are typically achieved within 1-2 hours. The drug is extensively bound to plasma proteins (approximately 90%). It is primarily excreted via the kidneys, with a significant portion also being eliminated via the bile. Elimination half-life varies depending on renal function. The drug can accumulate in patients with renal impairment. |
| suggested dosage | Dosage for fusidic acid varies significantly based on the condition being treated and patient characteristics. Consult with a healthcare professional for specific dosage recommendations. Always adhere to prescribed dosage and duration of therapy. |
| indications | | 1 | Bacterial skin and soft tissue infections (e.g., impetigo, cellulitis). | | 2 | Infections of the eye, such as conjunctivitis. | | 3 | Infections of the bone (osteomyelitis). | | 4 | Infections of the genital tract (e.g., bacterial vaginosis, pelvic inflammatory disease - in conjunction with other antibiotics). | | 5 | Infections caused by susceptible strains of bacteria (requires microbial susceptibility testing). | | 6 | A note regarding use of fusidic acid cream for acne; this is generally not a first-line treatment. |
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| safety in pregnancy | Fusidic acid crosses the placenta. Limited data suggest a potential risk to the developing fetus. Use during pregnancy is only considered if the potential benefit outweighs the potential risks. Consult with a healthcare provider. |
| safety in breastfeeding | Fusidic acid is excreted into breast milk. The potential risk to the infant is low, but consider discontinuing breastfeeding or using an alternative medication when possible during treatment. |
| side effects | | 1 | Gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea). | | 2 | Headache. | | 3 | Diarrhea (potentially severe or prolonged). | | 4 | Skin reactions (e.g., rash, itching). | | 5 | Elevated liver enzymes (monitor liver function tests if prescribed). | | 6 | Very rarely, potentially serious side effects like allergic reactions (e.g., anaphylaxis). |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to fusidic acid or other macrolide-like antibiotics. | | 2 | Significant liver disease. | | 3 | Severe renal impairment. |
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| interactions | | 1 | Concomitant use with certain drugs can alter effectiveness or increase the risk of side effects. Detailed interactions must be discussed with a prescribing physician. |
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| warnings and precautions | | 1 | Prolonged use of fusidic acid may increase risk of adverse events. Follow the prescribed regimen carefully. | | 2 | Monitor for signs of worsening infection or new infections during treatment. Seek immediate medical attention if symptoms worsen. | | 3 | Dosage adjustments may be needed in patients with renal impairment. Consult a healthcare professional. | | 4 | Avoid concurrent use with drugs that inhibit or induce drug metabolism. Consult a healthcare professional regarding all concomitant medications. |
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| additional informations | | 1 | Fusidic acid is available in various forms, including oral, topical creams, and eye drops. | | 2 | Proper hand hygiene and infection control are important in managing infections. |
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| patient details | | additional information | Patient details such as age and weight are important factors for appropriate dosage and safety considerations, but are not the sole determinants. Additional clinical information is necessary for a proper assessment. |
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