| name | Salmeterol Fluticasone |
| classification | Combination inhaler, long-acting beta2-agonist and inhaled corticosteroid for the prevention and treatment of asthma and chronic obstructive pulmonary disease (COPD). |
| pharmacokinetics | Salmeterol is a long-acting beta2-agonist that is primarily absorbed from the lungs. Fluticasone is an inhaled corticosteroid that is also absorbed from the lungs, with systemic absorption being minimal. The exact pharmacokinetic profiles in an individual can vary based on factors like lung function and age. |
| suggested dosage | Dosage is tailored to individual needs and should be determined by a physician. A typical starting point is often 2 puffs of fluticasone/salmeterol 250/50 mcg twice daily. Adjustments may be needed based on clinical response and tolerability. |
| indications | Used to prevent and treat asthma and chronic obstructive pulmonary disease (COPD). It is not intended for acute asthma attacks. |
| safety in pregnancy | Salmeterol/fluticasone use in pregnancy is generally avoided whenever possible. If use is necessary during pregnancy, it should be done under strict medical supervision to weigh potential benefits against potential risks. Consult with a healthcare provider. |
| safety in breastfeeding | Limited data is available on the excretion of salmeterol and fluticasone into breast milk. The decision to use salmeterol/fluticasone while breastfeeding should be made by a healthcare provider after considering the potential benefits and risks for both the mother and the infant. |
| side effects | | 1 | Upper respiratory infection (URI) (e.g., cough, sore throat, runny nose) | | 2 | Headache | | 3 | Hoarseness | | 4 | Oral candidiasis (thrush) | | 5 | Tremor (usually mild) | | 6 | Increased blood pressure | | 7 | Heart palpitations | | 8 | Muscle cramps | | 9 | Gastrointestinal upset (e.g., nausea, vomiting, heartburn) | | 10 | Skin reactions (e.g., rash) | | 11 | Dry mouth | | 12 | Anxiety | | 13 | Difficulty falling asleep or staying asleep | | 14 | Peripheral edema |
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| contraindications | | 1 | Known hypersensitivity to salmeterol or fluticasone propionate or other components of the drug | | 2 | Uncontrolled or poorly controlled glaucoma (increased eye pressure) | | 3 | Cardiac conditions such as arrhythmias | | 4 | Recent history of severe allergic reactions | | 5 | Hypersensitivity to other beta2-agonists or inhaled corticosteroids |
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| interactions | | 1 | Other medications, including other inhaled corticosteroids, bronchodilators, and medications that affect the cardiovascular system | | 2 | Use with other medications containing similar or related components must be reviewed by a healthcare provider. |
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| warnings and precautions | | 1 | Do not use this medication to treat acute symptoms of asthma or COPD. Use appropriate quick-relief medication. | | 2 | Monitor for signs of infection or thrush in the mouth. | | 3 | Advise patients to use the inhaler as prescribed and to report any adverse effects. | | 4 | Instruct patients to not stop using the medication without consulting their doctor. Gradually decreasing the dose can be crucial. | | 5 | Monitor blood pressure, heart rate and other relevant parameters as needed. |
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| alternatives | |
| additional informations | This information is not a substitute for professional medical advice. Always consult with a physician or other qualified healthcare provider before using this medication or making any decisions related to your health or treatment. |
| patient profile | |
