| name | Zafirlukast |
| classification | Leukotriene Receptor Antagonist |
| pharmacokinetics | | absorption | Well absorbed after oral administration. Peak plasma concentrations are usually reached within 1-2 hours. | | distribution | Distributes into various tissues, including the lungs. | | metabolism | Metabolized primarily in the liver, primarily by CYP2C8 and CYP3A4. | | excretion | Excreted in both urine and feces, with a half-life of approximately 10-12 hours. |
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| suggested dosage | | adults | 20 mg twice daily | | note | Dosage may vary based on individual needs and response. Consult with a healthcare professional for appropriate dosage. |
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| indications | | 1 | Prevention of exercise-induced bronchoconstriction | | 2 | Prevention of symptoms of chronic asthma (prophylaxis) |
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| safety in pregnancy | | category letter | C | | details | Limited data in pregnant women. Potential risks exist. Consult your physician. |
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| safety in breastfeeding | | status | Unknown | | details | Data on excretion in breast milk is limited. Potential risks cannot be ruled out. Consult your physician. |
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| side effects | | 1 | Headache | | 2 | Fatigue | | 3 | Nasopharyngitis (common cold symptoms) | | 4 | Nausea | | 5 | Abdominal pain | | 6 | Diarrhea | | 7 | Hepatic dysfunction (rare) | | 8 | Allergic reactions | | 9 | Skin rash | | 10 | Increased liver enzymes | | 11 | Gastrointestinal upset |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to zafirlukast or any of its components | | 2 | Severe liver dysfunction |
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| interactions | | 1 | May interact with other medications metabolized by CYP2C8 or CYP3A4 (e.g., certain antibiotics, antacids, antifungals). Consult your physician. |
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| warnings and precautions | | 1 | Monitor liver function tests, especially during initial therapy or dose adjustments. | | 2 | Discontinue if significant liver abnormalities occur. | | 3 | Use caution in patients with a history of liver disease. | | 4 | Use with caution in patients with pre-existing gastrointestinal issues. | | 5 | Seek immediate medical attention if allergic reaction occurs. |
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| additional informations | | 1 | Not for immediate relief of acute asthma attacks. It is a preventative medication. | | 2 | Patients should consult with their physician for personalized treatment plans. | | 3 | Individual responses may vary, and ongoing monitoring is necessary. | | 4 | This information is for educational purposes only and does not constitute medical advice. Consult your physician for diagnosis and treatment. |
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| patient information | | age | 25 | | weight | 70 | | units | kg | | note | General information. Specific dosing and precautions may vary based on individual factors. Consult with a healthcare professional. |
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