| drug | Clobetasol Propionate Ointment (High Potency) |
| name | Clobetasol Propionate Ointment (High Potency) |
| classification | Topical Corticosteroid, High Potency |
| pharmacokinetics | Clobetasol propionate is a potent topical corticosteroid that is primarily absorbed through the skin. Absorption varies considerably based on the area treated, the integrity of the skin barrier, and duration of application. Systemic absorption is generally low with topical application, but can be significant in cases of extensive skin involvement or prolonged use. The drug is primarily metabolized in the liver and excreted via the kidneys. Limited data are available on pharmacokinetic properties in specific populations. |
| suggested dosage | Dosage should be determined by the prescribing physician based on the specific condition and patient characteristics. Generally, a thin layer of ointment is applied to the affected area 1-2 times daily. Do not apply more than prescribed. Do not increase the frequency of application without consulting a physician. Avoid contact with the eyes. Discontinue use if irritation develops. |
| indications | Clobetasol propionate ointment (high potency) is indicated for the management of inflammatory dermatological conditions that respond to potent topical corticosteroids. Examples include severe plaque psoriasis, some types of dermatitis, and other inflammatory skin conditions. It should only be used under the guidance of a medical professional. |
| safety in pregnancy | Limited data are available on the safety of clobetasol propionate during pregnancy. Although systemic absorption is generally low, potential risks to the fetus are unclear. Therefore, use during pregnancy should be avoided whenever possible and only used under strict medical supervision if the potential benefit outweighs the risk. Consult your doctor. |
| safety in breastfeeding | Limited data are available on the safety of clobetasol propionate in breastfeeding mothers. Small amounts of the drug may be absorbed systemically and potentially enter breast milk. Due to the potential for adverse effects in the infant, clobetasol propionate ointment should be used with caution in breastfeeding women. Consult your doctor. |
| side effects | | 1 | Skin irritation (e.g., redness, burning, itching) | | 2 | Thinning of the skin (atrophy) | | 3 | Striae (stretch marks) | | 4 | Telangiectasia (small blood vessels dilation) | | 5 | Acneiform eruptions | | 6 | Hypopigmentation (loss of skin color) | | 7 | Systemic effects (rare, but possible with extensive use): Mood changes, Cushing's syndrome-like symptoms, adrenal suppression. |
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| contraindications | | 1 | Active skin infection (e.g., herpes simplex, bacterial infections) at the application site | | 2 | Patients with known hypersensitivity to clobetasol propionate or other topical corticosteroids | | 3 | Use on face or intertriginous areas (skin folds) should be approached with caution due to potential for more rapid absorption. |
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| interactions | Limited information on drug interactions. There may be interactions with other topical medications. Consult with a doctor about any other medications you are taking. |
| warnings | | 1 | Avoid prolonged or frequent use, especially in extensive or open areas of skin | | 2 | Do not use on damaged skin | | 3 | Do not use undiluted and directly on eyes | | 4 | Patients should be monitored for signs of systemic corticosteroid effects. |
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| precautions | | 1 | Patients with a history of skin conditions should be monitored closely | | 2 | Patients with a history of adrenal insufficiency may be at increased risk of systemic effects. | | 3 | Patients should not abruptly discontinue use of high-potency topical corticosteroids. Dosage should be tapered as needed by a physician. |
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| additional informations | This information is for general knowledge only and does not constitute medical advice. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment. This information does not cover all possible drug interactions or side effects. The information provided for suggested dosage, safety in pregnancy and breast feeding is general guidelines. It is crucial to consult with a doctor for personalized advice based on individual patient conditions. |
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