| name | Long-acting beta-agonists (LABAs) |
| classification | Bronchodilators |
| pharmacokinetics | LABAs primarily act by relaxing the smooth muscles of the airways, increasing airflow. Their duration of action varies, but they generally provide bronchodilation for several hours. Absorption and metabolism mechanisms vary depending on the specific LABA (e.g., salmeterol, formoterol). Excretion is primarily through the liver and kidneys. |
| suggested dosage | Dosage for LABAs is highly variable and depends on the specific drug, the patient's condition, and response. It's crucial to follow the prescribed dosage by a healthcare professional. Never adjust dosages without consulting a doctor. Generally, LABAs are administered via inhalation to deliver targeted action to the lungs. Some may be combined with inhaled corticosteroids for enhanced benefit. |
| indications | LABAs are primarily used to treat chronic obstructive pulmonary disease (COPD) and asthma. They can improve lung function, reduce exacerbations, and improve overall quality of life. |
| safety in pregnancy | LABAs are generally used with caution during pregnancy. There's limited data on the long-term effects, and potential risks to the developing fetus need careful consideration. Discuss with a doctor if pregnancy is possible or suspected. Some LABAs may be considered less risky than others. |
| safety in breastfeeding | Limited data is available for long-term safety in breastfeeding mothers. Some LABAs may be secreted in breast milk, although the level is usually not considered clinically significant. Consult with your healthcare provider to assess potential risks and benefits. |
| side effects | | 1 | Tremor | | 2 | Headache | | 3 | Nervousness | | 4 | Anxiety | | 5 | Increased heart rate | | 6 | Palpitations | | 7 | Muscle cramps | | 8 | Insomnia | | 9 | Increased blood pressure | | 10 | Rare cases of serious side effects (e.g., severe allergic reactions) |
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| contraindications | | 1 | Known hypersensitivity to LABAs | | 2 | Uncontrolled cardiovascular conditions (e.g., severe heart disease, uncontrolled hypertension) | | 3 | Severe hyperthyroidism |
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| interactions | | 1 | Certain medications (e.g., antidepressants, certain heart medications, and other bronchodilators) | | 2 | Possible interaction with other inhaled medications |
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| warnings and precautions | | 1 | LABAs should not be used as the sole treatment for asthma, but rather combined with other asthma medications. | | 2 | Regular monitoring of lung function and potential side effects is important. | | 3 | Do not abruptly discontinue LABA use without consulting your doctor. |
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| additional informations | | 1 | Patients with conditions like cardiovascular disease or diabetes require careful monitoring. | | 2 | Proper technique for inhaled medication is essential for optimal effectiveness and minimizing potential side effects. | | 3 | Individual responses to LABAs can vary, and adjustments to treatment may be necessary. | | 4 | Always consult a healthcare provider for appropriate prescription and dosage guidance. |
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