| name | Desloratadine |
| classification | Antihistamine, Non-sedating |
| pharmacokinetics | Desloratadine is a metabolite of loratadine. It is well absorbed orally, with peak plasma concentrations typically reached within 1-2 hours. It is extensively metabolized in the liver, primarily by cytochrome P450 enzymes (CYP3A4). The elimination half-life is approximately 27 hours, allowing for once-daily dosing. The drug is distributed throughout the body, with concentrations observed in various tissues. It is primarily eliminated in the urine as metabolites. |
| suggested dosage | | adults and adolescents (12 years and older) | 5 mg once daily | | children (6-12 years old) | 2.5 mg once daily | | children (2-5 years old) | 1.25mg once daily | | children (under 2 years): | consult a physician |
|
| indications | Desloratadine is used to relieve symptoms of seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives). |
| safety in pregnancy | Limited data is available on the use of desloratadine during pregnancy. While generally considered safe, pregnant women should consult with their doctor to discuss the risks and benefits of use. |
| safety in breastfeeding | Desloratadine is considered generally safe for use in breastfeeding mothers. However, mothers should consult their doctor before using the medication. |
| side effects | | 1 | Headache | | 2 | Fatigue | | 3 | Drowsiness | | 4 | Nausea | | 5 | Vomiting | | 6 | Diarrhea | | 7 | Dry mouth | | 8 | Skin rash | | 9 | Pruritus | | 10 | Urticaria |
|
| alternatives | |
| contraindications | | 1 | Known hypersensitivity to desloratadine or any of its ingredients | | 2 | Severe liver impairment |
|
| interactions | Desloratadine may interact with certain medications that affect the liver enzymes, and may also influence the efficacy or safety of certain other drugs. Consult a doctor about possible interactions with any other medications the patient is currently taking or any medication being prescribed. |
| warnings and precautions | | 1 | Do not exceed the recommended dosage. | | 2 | Monitor for signs of allergic reactions. | | 3 | Should be used with caution in patients with pre-existing liver disease | | 4 | Driving and operating machinery may be affected by potential side effects. Avoid these activities until the patient's response is fully assessed. |
|
| additional information | Desloratadine is available in tablet, syrup forms. It is not typically recommended for the treatment of acute anaphylaxis. |
| patient profile | |
